Primary Identifier | MGI:1917976 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 70726 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable signaling receptor binding activity. Predicted to be involved in angiogenesis; blood coagulation; and cell differentiation. Located in secretory granule. Is expressed in brain. Used to study obesity. Orthologous to human ANGPTL6 (angiopoietin like 6). PHENOTYPE: Most mice homozygous for a knock-out allele die around E13 with cardiovascular defects; survivors develop obesity, lipid accumulation in skeletal muscle and liver, hyperglycemia and hyperinsulinemia, and insulin resistance accompanied by reduced energy expenditure and whole-body oxygen consumption. [provided by MGI curators] |