| Primary Identifier | MGI:88047 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 11804 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity and serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including brain development; regulation of epidermal growth factor-activated receptor activity; and suckling behavior. Is active in spine apparatus. Is expressed in several structures, including compacted morula; heart; lower urinary tract; submandibular gland primordium; and ventral grey horn. Orthologous to human APLP2 (amyloid beta precursor like protein 2). PHENOTYPE: Homozygotes for two different targeted alleles show embryonic lethality, or viability and fertility with increased copper levels in cerebral cortex and liver. Double knockouts with App show high mortality, reduced growth, and neurological symptoms. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
