| Primary Identifier | MGI:1316743 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 20443 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity and beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in positive regulation of blood coagulation and positive regulation of leukocyte tethering or rolling. Acts upstream of or within protein glycosylation. Predicted to be located in Golgi cisterna membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Orthologous to human ST3GAL4 (ST3 beta-galactoside alpha-2,3-sialyltransferase 4). PHENOTYPE: Homozygotes for a null allele show thrombocytopenia, altered platelet physiology, increased bleeding times, and abnormal leukocyte migration. Homozygotes for a different null allele fail to develop seizures in response to kindling, and show anxiety-like behaviors and altered sleep patterns. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
