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Protein Coding Gene : Ddx25 DEAD box helicase 25
Primary Identifier  MGI:1353582 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  30959
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables ATP binding activity and RNA helicase activity. Involved in mRNA export from nucleus; regulation of translation; and spermatid development. Located in chromatoid body and nucleus. Is expressed in cortical plate; spermatid; and spermatocyte. Orthologous to human DDX25 (DEAD-box helicase 25).
PHENOTYPE: Homozygous null mice display male infertility, arrest of spermatogenesis at step 8, abnormal Leydig cells, and increased germ cell apoptosis in males. [provided by MGI curators]
  • synonyms:
  • Ddx25,
  • GRTH,
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 25,
  • MGI:2143278,
  • DEAD box helicase 25,
  • expressed sequence AW047046,
  • AW047046
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