| Primary Identifier | MGI:1921394 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 74144 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables signaling receptor activity. Acts upstream of or within negative regulation of blood vessel endothelial cell migration. Located in external side of plasma membrane. Is expressed in several structures, including forebrain; genitourinary system; neural retina; submandibular gland; and vascular system. Human ortholog(s) of this gene implicated in aortic valve disease 3. Orthologous to human ROBO4 (roundabout guidance receptor 4). PHENOTYPE: Homozygous knockout leads to enhanced VEGF-induced endothelial migration, tube formation and vascular permeability, and increased pathologic angiogenesis and vascular leak in models of oxygen-induced retinopathy and choroidal neovascularization. Homozygous KO also improves glucose metabolism and adipose tissue angiogenesis when fed high-fat diet and increases exercise endurance on normal chow. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
