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Protein Coding Gene : Robo3 roundabout guidance receptor 3
Primary Identifier  MGI:1343102 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  19649
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Involved in axon midline choice point recognition and commissural neuron axon guidance. Acts upstream of or within neuron migration. Located in axon. Is expressed in several structures, including central nervous system; cranial nerve; future brain; head mesenchyme; and sensory organ. Orthologous to human ROBO3 (roundabout guidance receptor 3).
PHENOTYPE: Homozygous mutants display perinatal lethality, abnormal commissural axon growth, and fragile floor plates. [provided by MGI curators]
  • synonyms:
  • roundabout guidance receptor 3,
  • Robo3a,
  • retinoblastoma inhibiting gene 1,
  • Rig1,
  • Rbig1,
  • Robo3,
  • Robo3b,
  • Rig-1
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