| Primary Identifier | MGI:1916774 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 69524 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cell-cell adhesion mediator activity. Acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Located in adherens junction; bicellular tight junction; and plasma membrane. Is expressed in several structures, including cardiovascular system; liver; lung; nervous system; and placenta. Orthologous to human ESAM (endothelial cell adhesion molecule). PHENOTYPE: Mice homozygous for a null allele exhbit a decrease in body weight, impaired neutrophil transmigration and decreased immune and VEGF-stimulated vascular permeability. Tumor growth is inhibited due to decreased pathological angiogenesis in homozygous mutant mice. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
