| Primary Identifier | MGI:1919419 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 72169 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables p53 binding activity. Acts upstream of or within negative regulation of protein localization to nucleus and negative regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in alimentary system; sensory organ; skin; and urethra. Orthologous to human TRIM29 (tripartite motif containing 29). PHENOTYPE: Homozygous inactivation of this gene protects male mice from Coxsackievirus B3-induced myocarditis by enhancing antiviral innate immunity, attenuating inflammation and cardiac damage, and improving cardiac function and survival rates. Primary neonatal cardiomyocytes from mice infected with cardiotropic viruses show reduced ER stress and apoptosis, decreased reactive oxygen species levels, and increased production of type I interferons. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
