Primary Identifier | MGI:1933114 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 80288 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables beta-catenin binding activity. Acts upstream of or within several processes, including canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including respiratory system cartilage; sensory organ; skeleton; trunk unsegmented mesenchyme; and vibrissa. Orthologous to human BCL9L (BCL9 like). PHENOTYPE: Mice homozygous for a null allele show lethality around E10.5-E11, embryonic growth arrest around E10, and complete block of branching morphogenesis and labyrinth layer formation in the placenta. [provided by MGI curators] |