Primary Identifier | MGI:103567 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 12145 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Acts upstream of or within leukocyte chemotaxis and lymph node development. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; extraembryonic component; liver; and retina. Orthologous to human CXCR5 (C-X-C motif chemokine receptor 5). PHENOTYPE: Homozygous null mutants lack inguinal lymph nodes, have a few abnormal or no Peyer's patches, morphologically altered primary lymphoid follicles and no functional germinal centers in their spleen. [provided by MGI curators] |