| Primary Identifier | MGI:106921 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 72821 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Acts upstream of or within with a positive effect on cardiac conduction and gene expression. Acts upstream of or within response to heat and sodium ion transport. Located in T-tubule. Is expressed in several structures, including cranial ganglion and dorsal root ganglion. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human SCN2B (sodium voltage-gated channel beta subunit 2). PHENOTYPE: Mice homozygous for a knock-out allele display decreased sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to pilocarpine-induced seizures but appear normal in other neurological tests. Impaired glucose tolerance in homozygous mutant males is seen. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
