| Primary Identifier | MGI:96282 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 15561 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity and ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be involved in several processes, including chemical synaptic transmission; inorganic cation transmembrane transport; and serotonin receptor signaling pathway. Part of serotonin-activated cation-selective channel complex. Is expressed in several structures, including central nervous system; eye; gallbladder; genitourinary system; and gut. Human ortholog(s) of this gene implicated in alcohol dependence; cocaine dependence; heroin dependence; irritable bowel syndrome; and nicotine dependence. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A). PHENOTYPE: Homozygous mice display a decreased lifespan, cachexia, increased blood urea nitrogen, proteinuria, kidney inflammation, and a hyperdistended and neurogenic urinary bladder. Mice homozygous for a second null mutation display reduced chemical pain persistence responses but are otherwise healthy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
