| Primary Identifier | MGI:107936 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 16173 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytokine activity. Involved in several processes, including cholesterol homeostasis; establishment of skin barrier; and positive regulation of cell differentiation. Acts upstream of or within several processes, including natural killer cell mediated cytotoxicity; negative regulation of myoblast differentiation; and positive regulation of type II interferon production. Is active in extracellular space. Is expressed in extraembryonic component; gut; lymphatic system; reproductive system; and trunk. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). PHENOTYPE: Mice homozygous for null alleles are deficient in producing IFN-gamma in response to infectious agents and have other impairments of the immune system. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
