Primary Identifier | MGI:1860140 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 56057 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA 3'-UTR binding activity. Acts upstream of or within maternal-to-zygotic transition of gene expression and negative regulation of mitotic cell cycle. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; early embryo; gonad; nasal cavity epithelium; and retina. Orthologous to human BTG4 (BTG anti-proliferation factor 4). PHENOTYPE: Female mice homozygous for mutations in this gene produce morphologically normal oocytes but exhibit defects during maternal-zygotic transition and are infertile because embryos arrest after fertilization at the 1- or 2-cell stage. [provided by MGI curators] |