Primary Identifier | MGI:1913652 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 66402 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable enzyme regulator activity. Involved in several processes, including positive regulation of cold-induced thermogenesis; regulation of ATPase-coupled calcium transmembrane transporter activity; and sarcoplasmic reticulum calcium ion transport. Acts upstream of or within negative regulation of ATPase-coupled calcium transmembrane transporter activity. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including diaphragm; embryo mesenchyme; heart atrium; musculature; and tongue. Orthologous to human SLN (sarcolipin). PHENOTYPE: Mice homozygous for a null allele exhibit increased cardiac contractility and impaired muscle-based thermogenesis. [provided by MGI curators] |