| Primary Identifier | MGI:1928268 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 64602 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables iron-responsive element binding activity. Involved in osteoclast differentiation. Acts upstream of or within several processes, including erythrocyte homeostasis; multicellular organismal-level iron ion homeostasis; and protoporphyrinogen IX biosynthetic process. Located in cytosol. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; nervous system; and yolk sac. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). PHENOTYPE: Homozygous disruption of this gene results in microcytic anemia, altered body iron homeostasis, and variable behavioral and neurological phenotypes that may include pathological signs of neurodegeneration or brain iron accumulation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
