Primary Identifier | MGI:1926014 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 71999 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of skeletal muscle fiber development. Located in cytoplasm and nucleus. Orthologous to human FBXO22 (F-box protein 22). PHENOTYPE: Mice homozygous for one null allele display infertility, decreased grip strength and decreased prepulse inhibition. Mice homozygous for a second null allele display partial lethality and decreased cell proliferation. [provided by MGI curators] |