| Primary Identifier | MGI:97591 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 18746 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA binding activity and pyruvate kinase activity. Involved in canonical glycolysis and positive regulation of cytoplasmic translation. Located in cilium and rough endoplasmic reticulum. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PKM (pyruvate kinase M1/2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased embryo size, absent egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5. Mice homozygous for a spontaneous allele exhibit prenatal lethality around the time of implantation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
