Primary Identifier | MGI:2442114 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 319480 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable collagen binding activity involved in cell-matrix adhesion; collagen receptor activity; and integrin binding activity. Acts upstream of or within fibroblast migration and substrate-dependent cell migration. Predicted to be located in focal adhesion. Predicted to be part of integrin alpha11-beta1 complex. Predicted to be active in external side of plasma membrane. Is expressed in brain meninges; limb; skeleton; tail paraxial mesenchyme; and thymus primordium. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ITGA11 (integrin subunit alpha 11). PHENOTYPE: Mice homozygous for a disruption of this gene display dwarfism, increased mortality with age, and defective incisors. [provided by MGI curators] |