| Primary Identifier | MGI:1913125 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 56469 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including SUMO ligase activity; transcription cis-regulatory region binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein sumoylation. Located in nuclear periphery. Is active in several cellular components, including glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Colocalizes with PML body. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; sensory organ; and trunk mesenchyme. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1). PHENOTYPE: Homozygous null mice display partial perinatal lethality, reduced body size, decreased susceptibility to viral infection, and increased susceptibility to bacterial infection and LPS-induced endotoxin shock. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
