Primary Identifier | MGI:1859170 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 50996 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in response to glucocorticoid. Acts upstream of or within RNA splicing; positive regulation of T cell apoptotic process; and positive regulation of apoptotic signaling pathway. Part of U2AF complex and spliceosomal complex. Is expressed in several structures, including brain ventricular layer; chondrocranium; jaw; submandibular gland primordium; and vibrissa. Orthologous to human PDCD7 (programmed cell death 7). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro outgrowth assays show that blastocysts hatch from the zona pellucida but form irregular outgrowths with no inner cell mass colony or trophoblast giant cells after 3 days in culture. [provided by MGI curators] |