Primary Identifier | MGI:1934919 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 93836 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including positive regulation of protein ubiquitination; positive regulation of transforming growth factor beta receptor signaling pathway; and protein polyubiquitination. Located in cytoplasm and nucleus. Part of protein-containing complex. Is expressed in several structures, including heart; nervous system; testis; and urinary system. Orthologous to human RNF111 (ring finger protein 111). PHENOTYPE: Mice homozygous for a gene trap allele fail to develop anterior structures and midline with failure to develop anterior endoderm, node and mesendoderm. [provided by MGI curators] |