| Primary Identifier | MGI:1914935 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 67685 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable nuclear estrogen receptor binding activity. Involved in axonemal dynein complex assembly; cilium movement; and determination of left/right symmetry. Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; heart development; and learning or memory. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and spleen. Used to study Robinow syndrome and primary ciliary dyskinesia 25. Human ortholog(s) of this gene implicated in dyslexia and primary ciliary dyskinesia 25. Orthologous to human DNAAF4 (dynein axonemal assembly factor 4). PHENOTYPE: Mice homozygous for a knock-out allele exhibit both pre- and postnatal lethality, hydrocephalus, and defects in organ laterality and ciliary motility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
