Primary Identifier | MGI:1196419 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 72278 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within positive regulation of transcription by RNA polymerase II and regulation of Rho guanyl-nucleotide exchange factor activity. Located in membrane. Is expressed in cranial ganglion; dorsal root ganglion; sensory organ; and skeleton. Orthologous to human CCPG1 (cell cycle progression 1). PHENOTYPE: Mice homozygous for a hypomorphic allele exhibit defective proteostasis within the lumen of the endoplasmic reticulum (ER) in pancreatic acinar cells, resulting in unrestricted ER stress and tissue injury of the exocrine pancreas. [provided by MGI curators] |