| Primary Identifier | MGI:1354946 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 50772 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables MAP kinase activity; protein heterodimerization activity; and protein kinase binding activity. Involved in protein phosphorylation. Acts upstream of or within positive regulation of dendritic spine development. Located in cytoplasm; nucleus; and septin cytoskeleton. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAPK6 (mitogen-activated protein kinase 6). PHENOTYPE: Homozygous null mice show limited fetal growth, reduced serum IGF2 levels, pulmonary hypoplasia and early neonatal death. About 40% of newborns die of acute respiratory failure exhibiting delayed lung maturation, reduced sacculation, atelectasis, and impaired type II pneumocyte differentiation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
