Primary Identifier | MGI:1309515 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 14860 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable glutathione transferase activity; organic cyclic compound binding activity; and toxic substance binding activity. Predicted to be involved in glutathione metabolic process and xenobiotic metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. PHENOTYPE: Mice homozygous for disruptions in this gene display increased sensitivity to oxidative stress, increased alanine and aspartate transaminase levels, increased susceptibility to bacterial infection, reduced litter size, and impaired glucose tolerance. [provided by MGI curators] |