| Primary Identifier | MGI:2442261 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 214763 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; molecular condensate scaffold activity; and poly-ADP-D-ribose modification-dependent protein binding activity. Involved in several processes, including cellular response to exogenous dsRNA; positive regulation of metabolic process; and regulation of defense response. Acts upstream of or within several processes, including determination of adult lifespan; regulation of T cell activation; and regulation of gene expression. Located in cytosol and plasma membrane. Is active in nucleus. Is expressed in central nervous system; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human CGAS (cyclic GMP-AMP synthase). PHENOTYPE: Mice homozygous for a null allele exhibit increased susceptibility to viral infection and abnormal innate immunity. Conditional expression of the p.R241E mutation in microglia leads to reduced spatial learning owing to hippocampal neuron degeneration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
