| Primary Identifier | MGI:1922283 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 75033 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in meiotic DNA double-strand break formation. Acts upstream of or within homologous chromosome pairing at meiosis; oogenesis; and spermatogenesis. Located in lateral element. Is expressed in spermatocyte. Orthologous to human MEI4 (meiotic double-stranded break formation protein 4). PHENOTYPE: Mice homozygous for a knock-out allele show meiotic defects including failure of double strand break formation and homologous synapsis. Mutant spermatocytes appear to arrest at a zygotene-like stage and undergo apoptosis while mutant ovaries show a nearly complete loss of follicles at adulthood. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
