Primary Identifier | MGI:1932404 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 83946 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable lysine-acetylated histone binding activity. Involved in several processes, including positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of mitotic nuclear division; and regulation of primary metabolic process. Acts upstream of or within several processes, including insulin receptor signaling pathway; positive regulation of cell population proliferation; and positive regulation of protein phosphorylation. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; female reproductive system; retina; and urinary system. Orthologous to human PHIP (pleckstrin homology domain interacting protein). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit postnatal and premature lethality associated with reduced body size, small myocardial cells and hepatocytes, hypoglycemia, increased insulin sensitivity, and reduced cell growth. [provided by MGI curators] |