Primary Identifier | MGI:2138069 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 94353 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of transcription by RNA polymerase II; and regulation of insulin secretion involved in cellular response to glucose stimulus. Located in nucleus. Is expressed in several structures, including central nervous system; epithelium; eye; genitourinary system; and limb. Orthologous to human HMGN3 (high mobility group nucleosomal binding domain 3). PHENOTYPE: Mice homozygous for a null allele exhibit impaired glucose tolerance with decreased insulin serum levels and increased glucose serum levels during feeding. [provided by MGI curators] |