Primary Identifier | MGI:97043 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 17436 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; nicotinamide nucleotide metabolic process; and protein homotetramerization. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human ME1 (malic enzyme 1). PHENOTYPE: Mice homozygous for a spontaneous allele exhibit decreased body weight on a medium fat diet, altered cytoplasmic malic enzyme activity, and a male-specific reduction in food intake on a high fat diet. [provided by MGI curators] |