| Primary Identifier | MGI:2386848 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 266690 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytochrome-b5 reductase activity, acting on NAD(P)H. Acts upstream of or within several processes, including glucose homeostasis; insulin secretion; and response to antibiotic. Located in endoplasmic reticulum. Is expressed in metanephros; nervous system; sensory organ; submandibular gland primordium; and thymus primordium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CYB5R4 (cytochrome b5 reductase 4). PHENOTYPE: Homozygous null mice exhibit defects in glucose homeostasis and pancreatic abnormalities consistent with symptoms of diabetes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
