| Primary Identifier | MGI:99782 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 23959 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 5'-nucleotidase activity. Involved in calcium ion homeostasis; inhibition of non-skeletal tissue mineralization; and purine ribonucleotide catabolic process. Acts upstream of or within adenosine biosynthetic process and negative regulation of inflammatory response. Located in plasma membrane. Is active in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and musculoskeletal system. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto). PHENOTYPE: Homozygous null mice for one allele are viable and fertile with increased circulating alkaline phosphatase and impaired tubuloglomerular feedback regulation. Homozygous null mice for a second allele display increased vascular permeability especially under hypoxic conditions. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
