| First Author | Berkemeier LR | Year | 1991 |
| Journal | Neuron | Volume | 7 |
| Issue | 5 | Pages | 857-66 |
| PubMed ID | 1742028 | Mgi Jnum | J:14604 |
| Mgi Id | MGI:62768 | Doi | 10.1016/0896-6273(91)90287-a |
| Citation | Berkemeier LR, et al. (1991) Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron 7(5):857-66 |
| abstractText | In vertebrates, the formation and maintenance of neuronal connections are subject to regulation by multiple target-derived, diffusible (neurotrophic) factors. Here we describe the identification and characterization of a novel neurotrophic factor designated neurotrophin-5 (NT-5). NT-5 is structurally related to nerve growth factor and is expressed in embryonic as well as adult tissues. Recombinant NT-5 promotes the survival of peripheral sensory and sympathetic neurons and induces differentiation of the pheochromocytoma cell line PC12. NT-5 activates two trk-related tyrosine kinase receptors and shares these receptors with other neurotrophins. Activation of multiple receptors may permit a single neurotrophin to control target innervation by distinct neuronal populations. Receptor sharing could enable neurotrophic factors emanating from distinct targets to cooperate in regulating neurons with multiple connections. |
