| Primary Identifier | MGI:107285 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 13036 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cysteine-type endopeptidase activator activity involved in apoptotic process; cysteine-type endopeptidase activity; and serine-type endopeptidase activity. Involved in several processes, including dichotomous subdivision of terminal units involved in lung branching; protein destabilization; and proteolysis. Acts upstream of or within positive regulation of apoptotic signaling pathway. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; cytoskeleton; and secretory granule. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including brain; egg cylinder; genitourinary system; gut gland; and lung. Orthologous to human CTSH (cathepsin H). PHENOTYPE: Mice homozygous for a reporter allele exhibit impaired lung surfactant and an abnormal eye globe with elongated axial length. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
