| Primary Identifier | MGI:1347346 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 108153 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables metallopeptidase activity. Involved in collagen fibril organization; proteoglycan metabolic process; and skeletal system development. Acts upstream of or within proteolysis. Located in cell surface and extracellular matrix. Is expressed in several structures, including bone; cartilage; embryo mesenchyme; and vibrissa. Orthologous to human ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif 7). PHENOTYPE: Homozygotes for a null allele show increased lung function parameters, reduced endothelial cell migration and proliferation, increased re-endothelialization and ameliorated neointima formation after carotid artery injury, and increased oval cell activation and biliary fibrosis after liver injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
