Primary Identifier | MGI:107201 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 22774 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; future brain; genitourinary system; and retina. Used to study Dandy-Walker syndrome. Orthologous to human ZIC4 (Zic family member 4). PHENOTYPE: Mice heterozygous for a knock-out allele exhibit posterior cerebellar hypoplasia and a mild defect in anterior cerebellar foliation. [provided by MGI curators] |