Primary Identifier | MGI:1891160 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 54371 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sulfotransferase activity. Involved in positive regulation of leukocyte tethering or rolling. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in trans-Golgi network. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human CHST2 (carbohydrate sulfotransferase 2). PHENOTYPE: Mice homozygous for a knock-out allele display decreased lymphocyte binding to peripheral lymph node high endothelial venules, and significantly reduced lymphocyte homing to Peyer's patches, peripheral and mesenteric lymph nodes. [provided by MGI curators] |