| Primary Identifier | MGI:109528 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 22063 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables store-operated calcium channel activity. Acts upstream of or within saliva secretion. Located in basolateral plasma membrane; membrane raft; and myofibril. Part of protein-containing complex. Is expressed in cochlea; dorsal root ganglion; skeletal muscle; spinal cord; and vagus ganglion. Orthologous to human TRPC1 (transient receptor potential cation channel subfamily C member 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased body weight and a severe loss of salivary gland fluid secretion due to attenuation of store-operated Ca2+ currents. Surprisingly, no abnormalities are seen in store-operated or mechanosensitive cation channels in vascular smooth muscle cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
