| Primary Identifier | MGI:1100856 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 17532 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTP-dependent protein binding activity; GTPase activity; and guanyl ribonucleotide binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; branchial arch; future spinal cord; limb bud; and liver. Human ortholog(s) of this gene implicated in Noonan syndrome 11. Orthologous to human MRAS (muscle RAS oncogene homolog). PHENOTYPE: Mice homozygous for an insertional mutation that inactivates the gene exhibit a decreased mean percentage of peripheral blood B cells but no other evidence of morphological or neurological defects; mutant astrocytes display normal responsiveness to different trophic factors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
