| Primary Identifier | MGI:1929209 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 56492 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity. Involved in several processes, including cellular response to estrogen stimulus; lung alveolus development; and tight junction assembly. Acts upstream of or within several processes, including negative regulation of bone resorption; negative regulation of osteoclast development; and negative regulation of tumor necrosis factor-mediated signaling pathway. Located in plasma membrane and tight junction. Is expressed in several structures, including gonadal fat pad; gut; male reproductive gland or organ; respiratory system; and skin. Orthologous to human CLDN18 (claudin 18). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased bone resorption and osteoclast differentiation. Homozygotes for another knock-out allele have impaired alveolarization and alveolar epithelial barrier function. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
