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Protein Coding Gene : Amotl2 angiomotin-like 2
Primary Identifier  MGI:1929286 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  56332
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables actin filament binding activity and identical protein binding activity. Involved in endothelial cell morphogenesis. Located in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including brain ventricular layer; dorsal aorta; gonad; telencephalon; and trophectoderm. Orthologous to human AMOTL2 (angiomotin like 2).
PHENOTYPE: Conditional homozygous knockout in endothelial cells during embryonic development leads to aortic restriction in the embryo. [provided by MGI curators]
  • synonyms:
  • C79691,
  • angiomotin-like 2,
  • mKIAA0989,
  • MGI:2143406,
  • MASCOT,
  • AW549739,
  • Amotl2,
  • expressed sequence AW549739,
  • expressed sequence C79691,
  • Lccp,
  • MGI:2143321
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