Primary Identifier | MGI:1346021 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 24059 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables prostaglandin transmembrane transporter activity. Acts upstream of or within prostaglandin transport. Predicted to be located in basal plasma membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including ganglia; nose; renal cortex; respiratory system; and skin. Human ortholog(s) of this gene implicated in primary hypertrophic osteoarthropathy. Orthologous to human SLCO2A1 (solute carrier organic anion transporter family member 2A1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit preinatel or early psotnatal lethality due to a patent ductus arteriosus and abnormal protaglandin metabolism. [provided by MGI curators] |