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Protein Coding Gene : Tmem108 transmembrane protein 108
Primary Identifier  MGI:1932411 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  81907
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Located in several cellular components, including axon; endosome; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in brain. Orthologous to human TMEM108 (transmembrane protein 108).
PHENOTYPE: Mice with drastically reduced expression exhibit decreased excitatory postsynaptic currents of dentate gyrate granule neurons, impaired sensorimotor gating, and behavioral deficits. [provided by MGI curators]
  • synonyms:
  • B130017P16Rik,
  • Tmem108,
  • RIKEN cDNA B130017P16 gene,
  • cDNA sequence, R74726,
  • R74726,
  • AI462967,
  • expressed sequence AI462967,
  • transmembrane protein 108,
  • MGI:2143066
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