| Primary Identifier | MGI:2181676 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 252837 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in early endosome; plasma membrane; and recycling endosome. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including central nervous system; gut; immune system; male reproductive gland or organ; and sensory organ. Orthologous to human ACKR4 (atypical chemokine receptor 4). PHENOTYPE: Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls. Mice homozygous for a different knock-out allele exhibit increased susceptibility to experimental autoimmune encephalomyelitis with increased Th17 response. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
