| Primary Identifier | MGI:1932389 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 81897 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including interleukin-1 receptor binding activity; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of intestinal epithelial cell development; and regulation of defense response. Acts upstream of or within several processes, including cellular response to chloroquine; negative regulation of ERK1 and ERK2 cascade; and regulation of macromolecule metabolic process. Located in cytoplasmic vesicle; endoplasmic reticulum; and plasma membrane. Is expressed in brain and intestine. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9). PHENOTYPE: Nullizygous mice exhibit impaired immune responses to CpG DNA and altered susceptibility to EAE and parasitic infection. ENU-induced mutants may exhibit altered susceptibility to viral infection or induced colitis and impaired immune response to unmethylated CpG oligonucleotides. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
