| Primary Identifier | MGI:1933196 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 81000 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including ATP binding activity; ATP hydrolysis activity; and transcription coregulator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nuclear speck. Is expressed in central nervous system; embryo; limb; and neural ectoderm. Orthologous to human RAD54L2 (RAD54 like 2). PHENOTYPE: Mice homozygous for a gene trap allele show embryonic growth retardation, reduced cell proliferation, increased neural tube apoptosis, and death by E11.5. Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths with a few adherent trophoblast giant cells after 3 days in culture. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
