| Primary Identifier | MGI:1196334 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 15587 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including hyalurononglucosaminidase activity; transforming growth factor beta binding activity; and virus receptor activity. Contributes to transcription coactivator activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; hyaluronan catabolic process; and positive regulation of protein import into nucleus. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; multicellular organismal-level iron ion homeostasis; and positive regulation of extrinsic apoptotic signaling pathway. Located in cell surface; membrane raft; and plasma membrane. Part of RNA polymerase II transcription regulator complex. Colocalizes with external side of plasma membrane. Is expressed in several structures, including alimentary system; heart; lateral plate mesoderm; respiratory system; and submandibular gland primordium. Orthologous to human HYAL2 (hyaluronidase 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality, poor survival, craniofacial defects including submucosal cleft palate, and mild anemia. Incompletely penetrant features include cor triatriatum sinister and hearing loss. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
