| Primary Identifier | MGI:1096377 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 22036 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin protein ligase activity. Involved in negative regulation of interferon-beta production and protein ubiquitination. Acts upstream of or within negative regulation of NF-kappaB transcription factor activity and signal transduction. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus and site of DNA damage. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina layer; and spleen. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein). PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality at prior to E8.5, embryonic growth retardation, decreased embryonic size, decreased cell proliferation and increased apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
