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Protein Coding Gene : Uba7 ubiquitin-like modifier activating enzyme 7
Primary Identifier  MGI:1349462 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  74153
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables ISG15 activating enzyme activity. Acts upstream of or within ISG15-protein conjugation and modification-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in liver lobe and thymus primordium. Orthologous to human UBA7 (ubiquitin like modifier activating enzyme 7).
PHENOTYPE: Homozygous null mice lacking ISG15 conjugation but not free ISG15 are healthy and fertile and exhibit normal antiviral responses against vesicular stomatitis virus and lymphocytic choriomeningitis virus infection. Bone-derived macrophages from mutant mice display normal responses to IFN treatment. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 1300004C08 gene,
  • MGI:1921403,
  • 1300004C08Rik,
  • Ube1l,
  • Uba7,
  • ubiquitin activating enzyme E1-like,
  • ubiquitin-like modifier activating enzyme 7,
  • ubiquitin-activating enzyme E1-like
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